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<\/div>\nJaponya\u2019da ger\u00e7ekle\u015ftirilen radikal bir k\u00f6k h\u00fccre nakli, korneas\u0131 a\u011f\u0131r hasar g\u00f6ren \u00fc\u00e7 ki\u015finin bulan\u0131k g\u00f6r\u00fc\u015f\u00fcn\u00fc \u00f6nemli \u00f6l\u00e7\u00fcde iyile\u015ftirdi. Bu klinik \u00e7al\u0131\u015fma, d\u00fcnyada t\u00fcr\u00fcn\u00fcn ilk \u00f6rne\u011fi olarak k\u00f6k h\u00fccre ara\u015ft\u0131rmalar\u0131nda b\u00fcy\u00fck bir ilerleme olarak de\u011ferlendiriliyor.<\/p>\n
Operasyondan iki y\u0131l sonra, herhangi bir ciddi g\u00fcvenlik sorunu ya\u015fanmazken, d\u0131\u015far\u0131dan bak\u0131ld\u0131\u011f\u0131nda \u00fc\u00e7 ki\u015finin de kornealar\u0131n\u0131n daha \u015feffaf bir g\u00f6r\u00fcn\u00fcm kazand\u0131\u011f\u0131 g\u00f6zlendi.<\/p>\n
\u00c7al\u0131\u015fmada, \u201climbal k\u00f6k h\u00fccre yetmezli\u011fi\u201d (LSCD) ad\u0131 verilen ve korneada yara dokusu birikimine yol a\u00e7an bir rahats\u0131zl\u0131\u011fa sahip d\u00f6rt kat\u0131l\u0131mc\u0131 yer ald\u0131.<\/p>\n
Limbus olarak adland\u0131r\u0131lan ve g\u00f6z\u00fcn beyaz k\u0131sm\u0131n\u0131 koruyarak korneay\u0131 destekleyen yap\u0131, k\u00f6k h\u00fccreler a\u00e7\u0131s\u0131ndan zengin bir b\u00f6lge olup korneadaki h\u00fccrelerin yenilenmesini sa\u011fl\u0131yor.<\/p>\n
Bu b\u00f6lgedeki k\u00f6k h\u00fccrelerin i\u015flevini kaybetmesi, zamanla g\u00f6rme kayb\u0131na yol a\u00e7\u0131yor. G\u00fcn\u00fcm\u00fczde LSCD\u2019ye sahip ki\u015filer bir g\u00f6zlerinden sa\u011fl\u0131kl\u0131 kornea dilimi ald\u0131rabiliyor ancak her iki g\u00f6z de etkilenmi\u015fse, bir don\u00f6r nakli gerekiyor.<\/p>\n
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<\/div>\nSa\u011fl\u0131kl\u0131 kan h\u00fccreleri kullan\u0131ld\u0131<\/strong> \u0130\u015fte bu noktada \u201cind\u00fcklenmi\u015f pluripotent k\u00f6k h\u00fccreler\u201d (iPSC) devreye giriyor. Herhangi bir insan h\u00fccresinden elde edilebilen bu k\u00f6k h\u00fccreler, embriyonik benzeri bir duruma yeniden programlanarak istenilen yeti\u015fkin h\u00fccre tipine d\u00f6n\u00fc\u015fme yetene\u011fine sahip.<\/p>\n Ge\u00e7en y\u0131l ABD\u2019li ara\u015ft\u0131rmac\u0131lar, limbal k\u00f6k h\u00fccreler kullanarak kornea hasar\u0131 olan iki hastan\u0131n g\u00f6rme yetisini geri kazand\u0131rd\u0131klar\u0131n\u0131 duyurmu\u015ftu. \u015eimdi ise Japonya\u2019daki Osaka \u00dcniversitesi Hastanesi\u2019ndeki bilim insanlar\u0131, sa\u011fl\u0131kl\u0131 insan kan h\u00fccrelerinden elde edilen iPSC\u2019leri kullanarak bir ad\u0131m daha ileri gitti ve hastalar\u0131n g\u00f6rme yetisini geri kazand\u0131rmay\u0131 ba\u015fard\u0131.<\/p>\n Uygulamalar hala deneysel ve potansiyel olarak riskli G\u00f6rme alan\u0131nda en iyi iyile\u015fme 44 ya\u015f\u0131ndaki kad\u0131n ve 66 ya\u015f\u0131ndaki erkek hastalarda g\u00f6zlendi. Ara\u015ft\u0131rmac\u0131lar, \u00fc\u00e7\u00fcnc\u00fc ve d\u00f6rd\u00fcnc\u00fc hastalarda, ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin nakil edilen h\u00fccrelere kar\u015f\u0131 geli\u015ftirdi\u011fi olumsuz bir tepki nedeniyle ayn\u0131 iyile\u015fmenin sa\u011flanamam\u0131\u015f olabilece\u011fini d\u00fc\u015f\u00fcn\u00fcyor.<\/p>\n Bu k\u00fc\u00e7\u00fck \u00f6l\u00e7ekli \u00e7al\u0131\u015fmalar umut verici olsa da, bu t\u00fcr uygulamalar hala deneysel ve potansiyel olarak riskli. Ara\u015ft\u0131rmac\u0131lar, gelecekte \u00e7ok merkezli klinik deneyler yapmay\u0131 ve elde edilen bu cesaret verici sonu\u00e7lar\u0131n \u00fczerine in\u015fa etmeyi planl\u0131yor.<\/p>\n \u00c7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131 The Lancet dergisinde yay\u0131mland\u0131.<\/p>\n<\/p><\/div>\n
K\u00fcresel olarak korneaya ba\u011fl\u0131 g\u00f6rme kayb\u0131 ya\u015fayan 12,7 milyon ki\u015finin yaln\u0131zca 70\u2019te 1\u2019i nakil \u015fans\u0131 bulabiliyor. Nakil imkan\u0131 olan ki\u015filer i\u00e7in dahi doku reddi riski bulunuyor.<\/p>\n
Laboratuvarda elde edilen iPSC\u2019ler, kornea epitel h\u00fccre tabakalar\u0131na (iCEPS) d\u00f6n\u00fc\u015ft\u00fcr\u00fcld\u00fc. Bu tabakalar, yara dokusu \u00e7\u0131kar\u0131lan kornean\u0131n \u00fczerine nakledilerek, koruyucu bir kontakt lensle kapat\u0131ld\u0131. Nakil sonras\u0131 yedi ay i\u00e7inde d\u00f6rt hastan\u0131n tamam\u0131nda g\u00f6rme iyile\u015fmesi g\u00f6zlendi. Ancak bir y\u0131l sonra, en a\u011f\u0131r g\u00f6rme kayb\u0131na sahip olan 39 ya\u015f\u0131ndaki 4. hastada g\u00f6rme tekrar geriledi.<\/p>\n