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<\/div>\nBilim insanlar\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k sisteminde \u201cdo\u011fal antibiyotiklerin kayna\u011f\u0131 olabilecek\u201d yeni bir b\u00f6l\u00fcm ke\u015ffetti.<\/p>\n
BBC\u2019nin haberine g\u00f6re, Avrupa Ara\u015ft\u0131rma Konseyi (ERC) taraf\u0131ndan desteklenen uzmanlar, bula\u015f\u0131c\u0131 hastal\u0131klar\u0131n tedavisini d\u00f6n\u00fc\u015ft\u00fcrebilecek yeni bir ke\u015fif yapt\u0131.<\/p>\n
Ke\u015fif, \u201cNature\u201d dergisinde \u201cprotein at\u0131klar\u0131 insan h\u00fccrelerinin savunma stratejisi olarak antibiyotiklere d\u00f6n\u00fc\u015ft\u00fcr\u00fcld\u00fc\u201d ba\u015fl\u0131kl\u0131 makalede yay\u0131mland\u0131.<\/p>\n
Buna g\u00f6re uzmanlar, h\u00fccrelerde proteinleri par\u00e7alayan \u201cproteazomlar\u0131n\u201d bakteriyel enfeksiyona kar\u015f\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k sistemine katk\u0131 sa\u011flad\u0131\u011f\u0131n\u0131 saptad\u0131.<\/p>\n
\u201c\u00c7\u00f6p kar\u0131\u015ft\u0131rma\u201d ad\u0131 verilen bilimsel s\u00fcre\u00e7 kapsam\u0131nda laboratuvarda b\u00fcy\u00fcyen bakteriler ve sepsisli fareler \u00fczerinde test yap\u0131ld\u0131.<\/p>\n
Bu s\u00fcre\u00e7te laboratuvarda h\u00fccreleri al\u0131n\u0131p proteazomu devre d\u0131\u015f\u0131 b\u0131rak\u0131lan Salmonella gibi bakterilerin enfekte edilmesi daha kolay hale geldi.<\/p>\n
Proteinleri geri d\u00f6n\u00fc\u015ft\u00fcren proteazomun, bakteri \u00f6ld\u00fcr\u00fcc\u00fc kimyasallardan olu\u015fan bir depo ortaya \u00e7\u0131karan gizli bir mekanizmas\u0131 oldu\u011fu belirlendi.<\/p>\n
H\u00fccre i\u00e7inde proteazomlar\u0131n, bakterileri tespit edebildi\u011fi ve bunun b\u00fcy\u00fcmesini durdurmak i\u00e7in kar\u015f\u0131 savunmalar olu\u015fturabildi\u011fi bulundu.<\/p>\n
Makalede, \u201cBu bulgular, bula\u015f\u0131c\u0131 hastal\u0131klarla m\u00fccadelede daha \u00f6nce tan\u0131mlanmam\u0131\u015f tedavi stratejilerinin \u00f6n\u00fcn\u00fc a\u00e7abilir\u201d ifadesi kullan\u0131ld\u0131.<\/p>\n
Ba\u011f\u0131\u015f\u0131kl\u0131k sistemindeki yeni ke\u015ffin, \u201cantimikrobiyal diren\u00e7li (AMR) enfeksiyonlarla m\u00fccadelede\u201d yayg\u0131n antibiyotiklere alternatif olu\u015fturabilece\u011fi iddia edildi.<\/p>\n
\u2013 \u201cYeni bir potansiyel do\u011fal antibiyotik s\u0131n\u0131f\u0131\u201d<\/p>\n
Weizmann Bilim Enstit\u00fcs\u00fcnden Prof. Yifat Merbl, ke\u015ffin \u201cbakteriyel enfeksiyona kar\u015f\u0131 savunma sa\u011flayan yeni ba\u011f\u0131\u015f\u0131kl\u0131k mekanizmas\u0131\u201d oldu\u011funu belirtti.<\/p>\n
Merbl, \u201cBu, v\u00fccudumuzun her yerinde, t\u00fcm h\u00fccrelerde ger\u00e7ekle\u015fiyor ve tamamen yeni bir potansiyel do\u011fal antibiyotik s\u0131n\u0131f\u0131 olu\u015fturuyor.\u201d dedi.<\/p>\n
\u2013 Daha fazla test ihtiyac\u0131<\/p>\n
Imperial College London Ya\u015fam Bilimleri B\u00f6l\u00fcm Ba\u015fkan\u0131 Profes\u00f6r Danile Davis, a\u00e7\u0131klamas\u0131nda, bulgular\u0131n \u201colduk\u00e7a ilgin\u00e7\u201d oldu\u011funu kaydetti.<\/p>\n
Ke\u015ffin \u201cyeni bir antibiyotik kayna\u011f\u0131na d\u00f6n\u00fc\u015ft\u00fcr\u00fclmesinin zaman alaca\u011f\u0131n\u0131\u201d kaydeden Davis, daha fazla test yap\u0131lmas\u0131 gerekti\u011fine dikkati \u00e7ekti.<\/p>\n
Davis, bunun yeni bir antibiyotik kayna\u011f\u0131na d\u00f6n\u00fc\u015ft\u00fcr\u00fclmesinin \u201chen\u00fcz test edilmesi gereken ve zaman alabilecek\u201d bir d\u00fc\u015f\u00fcnce oldu\u011funu bildirdi.<\/p>\n
\u2013 \u0130ngiltere \u201cteyakkuzda\u201d<\/p>\n
Hastal\u0131k ve enfeksiyonlar\u0131n yayg\u0131n tedavilerine yan\u0131t vermemesi olarak bilinen \u201cAMR\u201d k\u00fcresel bir sa\u011fl\u0131k sorunu olarak kabul ediliyor.<\/p>\n
Ulusal Denetim Ofisi (NAO) raporuna g\u00f6re, AMR her y\u0131l \u0130ngiltere\u2019de 7 bin 600 \u00f6l\u00fcmden do\u011frudan, 35 bin 200 \u00f6l\u00fcmden dolayl\u0131 olarak sorumlu.<\/p>\n
\u0130ngiltere Sa\u011fl\u0131k G\u00fcvenlik Ajans\u0131 yetkilisi Dr. Colin Brown ocakta, ajans\u0131n \u00fclke i\u00e7i ve d\u0131\u015f\u0131nda artan AMR vir\u00fcs\u00fc riskine kar\u015f\u0131 teyakkuzda oldu\u011funu s\u00f6ylemi\u015fti.<\/p>\n
AMR\u2019nin her y\u0131l k\u00fcresel \u00e7apta 1 milyondan fazla \u00f6l\u00fcme neden oldu\u011funa kaydeden Brown, \u201cEylemde bulunulmazsa, hayat kurtar\u0131c\u0131 tedavilerin bulunabilirli\u011fi d\u00fc\u015fecek ve enfeksiyonlar\u0131 azaltma yetene\u011fimiz azalacak\u201d demi\u015fti.<\/p>\n<\/p><\/div>\n