{"id":9135,"date":"2023-06-20T13:53:34","date_gmt":"2023-06-20T13:53:34","guid":{"rendered":"https:\/\/kibrisdakik.com\/index.php\/2023\/06\/20\/kolon-kanserinin-bagisiklik-sisteminin-savunma-duvarini-nasil-astigi-kesfedildi\/"},"modified":"2023-06-20T13:53:34","modified_gmt":"2023-06-20T13:53:34","slug":"kolon-kanserinin-bagisiklik-sisteminin-savunma-duvarini-nasil-astigi-kesfedildi","status":"publish","type":"post","link":"https:\/\/kibrisdakik.com\/?p=9135","title":{"rendered":"Kolon kanserinin ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin savunma duvar\u0131n\u0131 nas\u0131l a\u015ft\u0131\u011f\u0131 ke\u015ffedildi"},"content":{"rendered":"

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Birle\u015fik Krall\u0131k\u2019ta yap\u0131lan bir ara\u015ft\u0131rmada, kal\u0131n ba\u011f\u0131rsak kanseri olarak da bilinen kolon kanserinin ba\u011f\u0131\u015f\u0131kl\u0131k sistemini nas\u0131l \u201ck\u00f6r etti\u011fi\u201d ortaya kondu.<\/p>\n

Glasgow \u00dcniversitesinin a\u00e7\u0131klamas\u0131na g\u00f6re, \u00fcniversitenin Birle\u015fik Krall\u0131k\u2019taki Beaston Kanser Ara\u015ft\u0131rmalar\u0131 Enstit\u00fcs\u00fc ortakl\u0131\u011f\u0131nda y\u00fcr\u00fctt\u00fc\u011f\u00fc ara\u015ft\u0131rmada, kolon kanserinin ba\u015flad\u0131\u011f\u0131 ba\u011f\u0131rsa\u011f\u0131 \u00e7evreleyen epitel dokuda etkinlik g\u00f6steren \u201cgamma delta T\u201d ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri incelendi.<\/p>\n

Ba\u011f\u0131\u015f\u0131kl\u0131k sisteminde dola\u015farak zararl\u0131 organizmalarla sava\u015fan gamma delta T h\u00fccrelerinin, kolondaki t\u00fcm\u00f6r taraf\u0131ndan kodlar\u0131n\u0131n de\u011fi\u015ftirildi\u011fi ve bu sayede kanserin ba\u011f\u0131\u015f\u0131kl\u0131k sistemini savunmas\u0131z b\u0131rakt\u0131\u011f\u0131 biliniyordu.<\/p>\n

Ara\u015ft\u0131rmada, kolon kanserinin T h\u00fccrelerinin kodunu tekrar yazarak ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin savunma duvar\u0131n\u0131 nas\u0131l a\u015ft\u0131\u011f\u0131 ke\u015ffedildi.<\/p>\n

Bilim insanlar\u0131, ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerinde meydana gelen ve bir \u00e7e\u015fit \u201ck\u00f6rl\u00fck\u201d olarak tan\u0131mlanan de\u011fi\u015fimin \u00f6n\u00fcne ge\u00e7erek, h\u00fccrelerin kanserli dokular\u0131 \u201cg\u00f6rmesini\u201d sa\u011flamay\u0131 hedefliyor.<\/p>\n

Ara\u015ft\u0131rma ekibinin ba\u015f\u0131ndaki Dr. Seth Coffelt, \u201cKanser, ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerinin kendini tehdit olarak alg\u0131lamas\u0131n\u0131 istemez. Ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri \u201ck\u00f6rle\u015ferek\u201d kanseri tespit edemedi\u011finde ise v\u00fccuttaki y\u0131k\u0131m ba\u015flar.\u201d dedi.<\/p>\n

Coffelt, \u201ck\u00f6rle\u015fen\u201d T h\u00fccrelerinin kanserli dokular\u0131 \u201ctekrar g\u00f6rmesini\u201d sa\u011flayan bir ilac\u0131n geli\u015ftirilmesiyle, ba\u011f\u0131rsak kanserinin \u201cetkili\u201d tedavisinin \u00f6n\u00fcn\u00fcn a\u00e7\u0131labilece\u011fini vurgulad\u0131.<\/p>\n

D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fcne g\u00f6re 2020\u2019de d\u00fcnya genelinde 1,9 milyondan fazla yeni kolon kanseri vaka<\/a>s\u0131 tespit edildi ve 930 binden fazla ki\u015fi bu kanser t\u00fcr\u00fc nedeniyle hayat\u0131n\u0131 kaybetti.<\/p>\n

Ara\u015ft\u0131rman\u0131n sonu\u00e7lar\u0131 Amerikan Kanser Ara\u015ft\u0131rmalar\u0131 Birli\u011finin \u201cCancer Immunology Research\u201d dergisinde yay\u0131mland\u0131.<\/p>\n<\/p><\/div>\n